Ketamine Infusion Therapy Cost (2026)
Ketamine Infusion Therapy costs $350 - $800 nationally in 2026, with a median of $500. Pricing varies significantly by metro market, provider credentials, and case complexity.
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Evidence: IV ketamine has substantial published evidence for rapid antidepressant effects in treatment-resistant depression. Spravato (esketamine nasal spray) is the FDA-approved version. IV ketamine is used off-label.
Regulatory status: Ketamine is FDA-approved as anesthetic; use for depression is off-label. Performed by physicians or anesthetists.
About Ketamine Infusion Therapy
Ketamine infusion therapy uses sub-anesthetic IV ketamine to rapidly reduce symptoms of treatment-resistant depression, PTSD, and certain chronic pain conditions. Standard induction protocol is six infusions over 2-3 weeks with maintenance infusions as needed.
What it is
IV infusion of ketamine at sub-anesthetic dose (typically 0.5 mg/kg) over 40-60 minutes.
Who it is for
Adults with treatment-resistant depression (failed 2+ antidepressants), severe depression with suicidal ideation, PTSD, or specific chronic pain conditions.
What is typically included
- Psychiatric or medical screening
- Single infusion (40-60 minutes)
- Monitoring during and after
Procedure snapshot
- Category
- Mental Health
- Timeline
- 1 day
- Typical recovery
- 0 days
- Financing common
- Yes
- Evidence level
- FDA-Approved (Off-Label Use)
Cost factors
Initial 6-session series
Total cost for induction protocol.
Maintenance infusions
Ongoing sessions every 2-8 weeks.
Therapy integration
Ketamine-assisted psychotherapy adds $150-$250 per session.
Ketamine Infusion Therapy Cost by City
Median ketamine infusion therapy pricing across top US metros.
Financing Ketamine Infusion Therapy
Estimated monthly payments for the national median cost of $500.
Financing Options at $500
Estimated monthly payments for the median cost. Actual rates depend on credit and provider.
| Provider | Term | Est. APR | Est. Monthly | Apply |
|---|---|---|---|---|
| CareCredit | 24 months | 17.9% | $24.94/mo | Check rate → |
| Alphaeon Credit | 36 months | 14.9% | $17.31/mo | Check rate → |
| Proceed Finance | 60 months | 12.9% | $11.35/mo | Check rate → |
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Frequently asked questions
How much does a ketamine treatment series cost? +
The 6-infusion induction protocol typically runs $2,400 to $4,800 total. Maintenance infusions afterward run $350-$800 each.
Is ketamine therapy covered by insurance? +
Most insurance does not cover IV ketamine off-label. Spravato (the FDA-approved esketamine) is more frequently covered with prior authorization.
How often do I need ketamine infusions? +
Initial protocol is 6 infusions over 2-3 weeks. Maintenance varies widely; some patients need infusions every 2-3 weeks, others every 2-3 months.
How long do effects last? +
Acute antidepressant effects typically last 1-2 weeks after a single infusion. Series treatment extends benefit for 2-4 months in many responders.
Is ketamine therapy safe? +
When administered at sub-anesthetic dose under medical monitoring, IV ketamine has a strong safety profile. Common short-term effects include dissociation, nausea, and brief blood pressure elevation.